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Adverse events of sacubitril/valsartan: A meta-analysis of randomized controlled trials

although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters ( MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)

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Following 24 hours of treatment, cells were washed with phosphate buffered saline (PBS 1X) and stored at 80C